Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo

Molecular Pain

Table 1 Summary of results

Superfusate	Concentration	C-fibre response (% control)	n
ACSF	-	160% ± 13%*	5
DMSO	25%	150% ± 14%*	3
Mibefradil	5 mM	108% ± 14% n.s.	5
L-703,606	5 mM	88% ± 15%*	5
Dantrolene	500 μM	103% ± 14% n.s.	5
U-73122	500 μM	107% ± 10% n.s.	5
Chelerythrine	800 μM	103% ± 7% n.s.	5
D-AP5	100 μM	107% ± 8% n.s	5
KN-93	400 μM	99% ± 5% n.s	5

Mean (± SEM) C-fibre evoked field potentials are expressed as % of control 60 min after LFS. One-way repeated measure-ANOVA was used to compare areas of C-fibre evoked field potentials before and after LFS. The asterisk denotes significant differences from baseline (* = p < 0.05). Drugs in spinal superfusate and their respective concentrations are indicated.

ISSN: 1744-8069