Table 1 P2X3 and P2X2/3 receptor antagonists
From: Purinergic mechanosensory transduction and visceral pain
Antagonist | P2X3 | P2X2/3 |
|---|---|---|
Suramin and analogues NF449, NF110 | √ | √ |
PPADS and derivatives MRS2159 & MRS2257 | √√ | √ |
Reactive blue 2 and derivatives TNP-ATP | √ | √ |
A-317491 (selective) | √√√ | √√√ |
Phenol red | √√√ | √√√ |
Tetramethylpyrazine | √√ | - |
RO4 (orally bioavailable, stable in vivo) | √√ | ? |
Ip5I | √√ | √√ |
βγcarboxymethylene ATP | √√ | - |
βγchlorophosphnomethylene ATP | ? | √√ |
|  | ? | √√ |