Table 2 Electrophysiological characteristics of LI neurons from adult mice (Ward’s)
| Â | SF | sAHP | fAHP | ADP1 | ADP2 |
|---|---|---|---|---|---|
|  | (N = 4) | (N = 18) | (N = 11) | (N = 29) | (N = 6) |
Ri (MΩ) | 1575.0 ± 103.1a | 443.5 ± 37.8 | 421.3 ± 51.0 | 476.0 ± 44.5 | 413.3 ± 42.8 |
SF >> sAHP, fAHP, ADP1, ADP2 | |||||
Cm (pF) | 18.2 ± 4.4a | 44.0 ± 3.2 | 44.7 ± 4.2 | 47.0 ± 4.2 | 58.2 ± 8.9 |
sAHP, fAHP, ADP1, ADP2 >> SF | |||||
Tau (ms) | 42.0 ± 5.9 | 21.6 ± 1.1 | 18.5 ± 2.0 | 27.1 ± 2.1 | 39.3 ± 8.5 |
SF, ADP2 > sAHP, fAHP, ADP1 | |||||
RMP (mV) | −56.2 ± 5.1 | −64.8 ± 1.7 | −69.6 ± 1.4 | −63.1 ± 1.3 | −60.7 ± 2.9 |
SF > fAHP | |||||
Rheobase (pA) | 0 | 63.9 ± 10.4 | 71.8 ± 9.4 | 28.7 ± 4.1 | 30.8 ± 11.0 |
sAHP, fAHP > SF, ADP1, ADP2 | |||||
Amplitude (mV) | 73.1 ± 7.3 | 63.2 ± 3.2c | 80.9 ± 4.8 | 95.7 ± 2.4a | 60.7 ± 3.7 |
ADP1>> SF, sAHP, fAHP, ADP2; fAHP > sAHP, ADP2 | |||||
First spike latency (ms) | 192.6 ± 15.3 | 313.7 ± 28.7 | 229.0 ± 38.3 | 184.6 ± 15.1 | 240.4 ± 47.3 |
sAHP >> ADP1 | |||||
Amplitude of early frequency adaptation (Hz) | 44.9 ± 7.3 | 75.3 ± 5.3 | 66.0 ± 9.9 | 99.7 ± 8.3a | 50.9 ± 7.5 |
ADP1>> SF, sAHP, fAHP, ADP2 | |||||
Time constant of early adaptation (ms) | 21.8 ± 4.9 | 25.5 ± 2.9 | 30.1 ± 3.7 | 23.5 ± 1.7 | 55.6 ± 11.3a |
ADP2 >> ADP1, SF, sAHP, fAHP | |||||
Slope of late adaptation (Hz/s) | −12.3 ± 5.4 | −23.8 ± 4.6 | −33.5 ± 6.7 | −38.4 ± 4.5b | −4.5 ± 10.4 |
ADP2 > ADP1 | |||||
Maximal steady-state frequency (Hz) | 41.7 ± 5.5 | 43.8 ± 2.4 | 48.9 ± 5.1 | 62.2 ± 4.0b | 31.6 ± 3.3 |
ADP1 > ADP2 | |||||
Duration increase | 27.7 ± 8.6 | 25.2 ± 2.6 | 20.3 ± 1.3 | 10.2 ± 1.0a | 19.9 ± 4.7 |
SF, sAHP, fAHP, ADP2 >> ADP1 | |||||
Threshold (mV) | −52.5 ± 1.5a | −37.9 ± 1.4 | −36.9 ± 1.2 | −42.0 ± 0.8 | −41.3 ± 1.1 |
sAHP, fAHP, ADP1, ADP2 >> SF; sAHP, fAHP > ADP1 | |||||
Half width (ms) | 1.55 ± 0.14 | 1.76 ± 0.07c | 1.34 ± 0.07 | 1.08 ± 0.03a | 1.65 ± 0.04 |
SF, sAHP, fAHP, ADP2 >> ADP1; sAHP, ADP2 > fAHP | |||||
Rise time (ms) | 0.65 ± 0.03 | 0.69 ± 0.02 | 0.66 ± 0.02 | 0.59 ± 0.01b | 0.76 ± 0.02 |
sAHP, fAHP, ADP2 > ADP1 | |||||
Decay time (ms) | 1.67 ± 0.24 | 1.63 ± 0.08c | 1.10 ± 0.10 | 0.78 ± 0.03a | 1.48 ± 0.08 |
SF, sAHP, ADP2 > fAHP >> ADP1 | |||||