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  1. Cultured sensory neurons are a common experimental model to elucidate the molecular mechanisms of pain transduction typically involving activation of ATP-sensitive P2X or capsaicin-sensitive TRPV1 receptors. T...

    Authors: Manuela Simonetti, Alessandra Fabbro, Marianna D'Arco, Marina Zweyer, Andrea Nistri, Rashid Giniatullin and Elsa Fabbretti

    Citation: Molecular Pain 2006 2:11

    Content type: Research

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  2. Triptans, 5-HT1B/ID agonists, act on peripheral and/or central terminals of trigeminal ganglion neurons (TGNs) and inhibit the release of neurotransmitters to second-order neurons, which is considered as one of k...

    Authors: Tomoko Morikawa, Yoshiyasu Matsuzawa, Koshi Makita and Yoshifumi Katayama

    Citation: Molecular Pain 2006 2:10

    Content type: Research

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  3. Intradermal injection of capsaicin into the hind paw of rats induces spinal cord central sensititzation, a process in which the responsiveness of central nociceptive neurons is amplified. In central sensitizat...

    Authors: Xuan Zhang, Jing Wu, Yongzhong Lei, Li Fang and William D Willis

    Citation: Molecular Pain 2006 2:9

    Content type: Short report

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  4. In this study, we show that capsaicin (CAP) depresses primary afferent fiber terminal excitability by acting on vanilloid receptor 1 (TRPV1 channels) of primary afferent fibers in adenosine 5'-triphosphate (AT...

    Authors: Kei Kusudo, Hiroshi Ikeda and Kazuyuki Murase

    Citation: Molecular Pain 2006 2:8

    Content type: Research

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  5. The Ca2+/calmodulin-stimulated adenylyl cyclase (AC) isoforms AC1 and AC8, couple NMDA receptor activation to cAMP signaling pathways in neurons and are important for development, learning and memory, drug addict...

    Authors: Kunjumon I Vadakkan, Hansen Wang, Shanelle W Ko, Evelyn Zastepa, Michele J Petrovic, Kathleen A Sluka and Min Zhuo

    Citation: Molecular Pain 2006 2:7

    Content type: Research

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  6. Intrathecal (IT) gene transfer is an attractive approach for targeting spinal mechanisms of nociception but the duration of gene expression achieved by reported methods is short (up to two weeks) impairing the...

    Authors: Benjamin Storek, Nina M Harder, Michaela S Banck, Cheng Wang, Douglas M McCarty, William GM Janssen, John H Morrison, Christopher E Walsh and Andreas S Beutler

    Citation: Molecular Pain 2006 2:4

    Content type: Methodology

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  7. N-methyl-D-aspartic acid (NMDA) spinal cord receptors play an important role in the development of hyperalgesia following inflammation. It is unclear, however, if changes in NMDA subunit receptor gene expressi...

    Authors: QiQi Zhou, Robert M Caudle, Donald D Price, Arseima Y Del Valle-Pinero and G Nicholas Verne

    Citation: Molecular Pain 2006 2:3

    Content type: Research

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  8. Numerous studies have implicated spinal extracellular signal-regulated kinases (ERKs) as mediators of nociceptive plasticity. These studies have utilized pharmacological inhibition of MEK to demonstrate a role...

    Authors: Farzana Karim, Hui-Juan Hu, Hita Adwanikar, David Kaplan and Robert W Gereau IV

    Citation: Molecular Pain 2006 2:2

    Content type: Research

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  9. Most current methods for assessing pain in animals are based on reflexive measures and require constant interaction between the observer and the animal. Here we explore two new fully automated methods to quant...

    Authors: Rami Jabakhanji, Jennifer M Foss, Hugo H Berra, Maria V Centeno, A Vania Apkarian and Dante R Chialvo

    Citation: Molecular Pain 2006 2:1

    Content type: Methodology

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  10. ASIC3, the most sensitive of the acid-sensing ion channels, depolarizes certain rat sensory neurons when lactic acid appears in the extracellular medium. Two functions have been proposed for it: 1) ASIC3 might...

    Authors: Derek C Molliver, David C Immke, Leonardo Fierro, Michel Paré, Frank L Rice and Edwin W McCleskey

    Citation: Molecular Pain 2005 1:35

    Content type: Research

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  11. We use fMRI to examine brain activity for pain elicited by palpating joints in a single patient suffering from psoriatic arthritis. Changes in these responses are documented when the patient ingested a single ...

    Authors: M Baliki, J Katz, DR Chialvo and AV Apkarian

    Citation: Molecular Pain 2005 1:32

    Content type: Short report

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  12. We have developed a highly effective method for in vivo gene silencing in the spinal cord and dorsal root ganglia (DRG) by a cationic lipid facilitated delivery of synthetic, small interfering RNA (siRNA). A siRN...

    Authors: Miaw-Chyi Luo, Dong-Qin Zhang, Shou-Wu Ma, Yuan-Yuan Huang, Sam J Shuster, Frank Porreca and Josephine Lai

    Citation: Molecular Pain 2005 1:29

    Content type: Methodology

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  13. TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as capsaicin, as well as by acidic conditions and temperatures above 42°C. These activators can enhance the potency of one anot...

    Authors: Torben R Neelands, Michael F Jarvis, Ping Han, Connie R Faltynek and Carol S Surowy

    Citation: Molecular Pain 2005 1:28

    Content type: Research

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  14. Neonatal noxious insult produces a long-term effect on pain processing in adults. Rats subjected to carrageenan (CAR) injection in one hindpaw within the sensitive period develop bilateral hypoalgesia as adult...

    Authors: Ke Ren, Svetlana I Novikova, Fang He, Ronald Dubner and Michael S Lidow

    Citation: Molecular Pain 2005 1:27

    Content type: Research

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  15. Strong noxious stimuli cause plastic changes in spinal nociceptive neurons. Intracellular signal transduction pathways from cellular membrane to nucleus, which may further regulate gene expression by critical ...

    Authors: Jing Wu, Guangxiao Su, Long Ma, Xuan Zhang, Yongzhong Lei, Junfa Li, Qing Lin and Li Fang

    Citation: Molecular Pain 2005 1:26

    Content type: Research

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  16. Spinal cord N-methyl-D-aspartate (NMDA) receptors are intimately involved in the development and maintenance of central sensitization. However, the mechanisms mediating the altered function of the NMDA recepto...

    Authors: Robert M Caudle, Federico M Perez, Arseima Y Del Valle-Pinero and Michael J Iadarola

    Citation: Molecular Pain 2005 1:25

    Content type: Research

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  17. In mammals, somatosensory input activates feedback and feed-forward inhibitory circuits within the spinal cord dorsal horn to modulate sensory processing and thereby affecting sensory perception by the brain. ...

    Authors: Terumasa Nakatsuka, Meng Chen, Daisuke Takeda, Christopher King, Jennifer Ling, Hong Xing, Toyofumi Ataka, Charles Vierck, Robert Yezierski and Jianguo G Gu

    Citation: Molecular Pain 2005 1:20

    Content type: Research

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  18. The present study examined whether pre-injury administration of morphine can prevent partial sciatic nerve injury-induced neuropathic pain in mice. We observed that pre-injury administration of subcutaneous (s...

    Authors: Md Harunor Rashid and Hiroshi Ueda

    Citation: Molecular Pain 2005 1:19

    Content type: Research

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  19. Well-established methods are available to measure thermal and mechanical sensitivity in awake behaving rats. However, they require experimenter manipulations and tend to emphasize reflexive behaviors. Here we ...

    Authors: Marwan Baliki, Oscar Calvo, Dante R Chialvo and A Vania Apkarian

    Citation: Molecular Pain 2005 1:18

    Content type: Methodology

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  20. Insulin and insulin-like growth factors (IGFs) maintain vital neuronal functions. Absolute or functional deficiencies of insulin or IGF-I may contribute to neuronal and vascular complications associated with d...

    Authors: Jeremy J Van Buren, Satyanarayan Bhat, Rebecca Rotello, Mary E Pauza and Louis S Premkumar

    Citation: Molecular Pain 2005 1:17

    Content type: Research

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  21. Divalent metal ions such as copper, manganese, and cobalt are essential for cell development, differentiation, function and survival. These essential metal ions are delivered into intracellular domains as cofa...

    Authors: Dehuang Guo, Jennifer Ling, Mong-Heng Wang, Jin-Xiong She, Jianguo Gu and Cong-Yi Wang

    Citation: Molecular Pain 2005 1:15

    Content type: Research

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  22. An emerging theme in systems neurobiology is that even simple forms of memory depend on activity in a broad network of cortical and subcortical brain regions. One key challenge is to understand how different c...

    Authors: Paul W Frankland and Cátia M Teixeira

    Citation: Molecular Pain 2005 1:14

    Content type: Commentary

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  23. Transcutaneous sine-wave stimuli at frequencies of 2000, 250 and 5 Hz (Neurometer) are thought to selectively activate Aβ, Aδ and C afferent fibers, respectively. However, there are few reports to test the sel...

    Authors: Kohei Koga, Hidemasa Furue, Md Harunor Rashid, Atsushi Takaki, Toshihiko Katafuchi and Megumu Yoshimura

    Citation: Molecular Pain 2005 1:13

    Content type: Research

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  24. The ability to feel hot and cold is critical for animals and human beings to survive in the natural environment. Unlike other sensations, the physiology of cold sensation is mostly unknown. In the present stud...

    Authors: Susan J Kim, Zhican Qu, Jeffrey Milbrandt and Min Zhuo

    Citation: Molecular Pain 2005 1:11

    Content type: Short report

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  25. Despite many decades of drug development, effective therapies for neuropathic pain remain elusive. The recent recognition of spinal cord glia and glial pro-inflammatory cytokines as important contributors to n...

    Authors: Erin D Milligan, Evan M Sloane, Stephen J Langer, Pedro E Cruz, Marucia Chacur, Leah Spataro, Julie Wieseler-Frank, Sayamwong E Hammack, Steven F Maier, Terence R Flotte, John R Forsayeth, Leslie A Leinwand, Raymond Chavez and Linda R Watkins

    Citation: Molecular Pain 2005 1:9

    Content type: Research

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  26. Identifying higher brain central region(s) that are responsible for the unpleasantness of pain is the focus of many recent studies. Here we show that direct stimulation of the anterior cingulate cortex (ACC) i...

    Authors: Jianrong Tang, Shanelle Ko, Hoi-Ki Ding, Chang-Shen Qiu, Amelita A Calejesan and Min Zhuo

    Citation: Molecular Pain 2005 1:6

    Content type: Research

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  27. Prostaglandin E2 (PGE2) and prostaglandin I2 (PGI2) are major inflammatory mediators that play important roles in pain sensation and hyperalgesia. The role of their receptors (EP and IP, respectively) in inflamma...

    Authors: Tomoko Moriyama, Tomohiro Higashi, Kazuya Togashi, Tohko Iida, Eri Segi, Yukihiko Sugimoto, Tomoko Tominaga, Shuh Narumiya and Makoto Tominaga

    Citation: Molecular Pain 2005 1:3

    Content type: Research

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  28. Propofol is a widely used intravenous general anesthetic. Propofol-induced unconsciousness in humans is associated with inhibition of thalamic activity evoked by somatosensory stimuli. However, the cellular me...

    Authors: Shui-Wang Ying and Peter A Goldstein

    Citation: Molecular Pain 2005 1:2

    Content type: Research

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  29. Molecular pain is a relatively new and rapidly expanding research field that represents an advanced step from conventional pain research. Molecular pain research addresses physiological and pathological pain a...

    Authors: Jianguo Gu, Min Zhuo, Michael Caterina, Amy B MacDermott, Annika Malmberg, Volker Neugebauer and Megumu Yoshimura

    Citation: Molecular Pain 2005 1:1

    Content type: Editorial

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