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  1. It has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. Less is known about the possible contribution of microglia to corti...

    Authors: Qian Song, Ming-Gang Liu and Min Zhuo

    Citation: Molecular Pain 2015 11:25

    Content type: Research

    Published on:

    A Erratum has been published.

  2. Mammals use tactile end-organs to perform sensory tasks such as environmental exploration, social interaction, and tactile discrimination. However, cellular and molecular mechanisms underlying tactile transduc...

    Authors: Ryo Ikeda, Jennifer Ling, Myeounghoon Cha and Jianguo G Gu

    Citation: Molecular Pain 2015 11:23

    Content type: Methodology

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  3. Laser in-situ keratomileusis (LASIK) is a commonly performed surgical procedure used to correct refractive error. LASIK surgery involves cutting a corneal flap and ablating the stroma underneath, with known da...

    Authors: Alexandra E Levitt, Anat Galor, Jayne S Weiss, Elizabeth R Felix, Eden R Martin, Dennis J Patin, Konstantinos D Sarantopoulos and Roy C Levitt

    Citation: Molecular Pain 2015 11:21

    Content type: Review

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  4. Transient receptor potential (TRP) channels are nonselective cation channels expressed in a variety of sensory structures, and are important molecular mediators of thermal, mechanical, cellular and chemical si...

    Authors: Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Hiroshi Hashizume, Hiroshi Yamada, Munehito Yoshida and Terumasa Nakatsuka

    Citation: Molecular Pain 2015 11:20

    Content type: Research

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  5. The Methyl CpG binding protein 2 gene (MeCP2 gene) encodes a critical transcriptional repressor and is widely expressed in mammalian neurons. MeCP2 plays a critical role in neuronal differentiation, neural develo...

    Authors: Ran Zhang, Min Huang, Zhijuan Cao, Jieyu Qi, Zilong Qiu and Li-Yang Chiang

    Citation: Molecular Pain 2015 11:19

    Content type: Short report

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  6. Mechanical and in particular tactile allodynia is a hallmark of chronic pain in which innocuous touch becomes painful. Previous cholera toxin B (CTB)-based neural tracing experiments and electrophysiology stud...

    Authors: Yi Zhang, Yong Chen, Wolfgang Liedtke and Fan Wang

    Citation: Molecular Pain 2015 11:18

    Content type: Short report

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  7. Superficial dorsal horn (SDH) neurons process nociceptive information and their excitability is partly determined by the properties of voltage-gated sodium channels. Recently, we showed the excitability and ac...

    Authors: Melissa A Tadros, Kristen E Farrell, Brett A Graham, Alan M Brichta and Robert J Callister

    Citation: Molecular Pain 2015 11:17

    Content type: Research

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  8. The activation of Translocator protein (18 kDa) (TSPO) has been demonstrated to mediate rapid anxiolytic efficacy in stress response and stress-related disorders. This protein is involved in the synthesis of e...

    Authors: Dong-sheng Wang, Zhen Tian, Yan-yan Guo, Hong-liang Guo, Wen-bo Kang, Shuo Li, Ya-ting Den, Xu-bo Li, Bing Feng, Dan Feng, Jian-ning Zhao, Gang Liu and Ming-gao Zhao

    Citation: Molecular Pain 2015 11:16

    Content type: Research

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  9. Lumbar disc herniation (LDH) is a major cause of discogenic low back pain and sciatica, but the underlying mechanisms remain largely unknown. Hydrogen sulfide (H2S) is becoming recognized for its involvement in a...

    Authors: Qianliang Wang, Hongyan Zhu, Kang Zou, Bo Yuan, You-Lang Zhou, Xinghong Jiang, Jun Yan and Guang-Yin Xu

    Citation: Molecular Pain 2015 11:15

    Content type: Research

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  10. Emerging research seeking novel analgesic drugs focuses on agents targeting group-II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors). N-Acetylcysteine (NAC) enhances the endogenous activation of m...

    Authors: Andrea Truini, Serena Piroso, Erica Pasquale, Serena Notartomaso, Giulia Di Stefano, Roberta Lattanzi, Giuseppe Battaglia, Ferdinando Nicoletti and Giorgio Cruccu

    Citation: Molecular Pain 2015 11:14

    Content type: Research

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  11. Tendinopathies are pathological conditions of tissue remodelling occurring in the major tendons of the body, accompanied by excessive nociceptive signalling. Tendinopathies have been shown to exhibit an increa...

    Authors: Jens Christensen, Håkan Alfredson and Gustav Andersson

    Citation: Molecular Pain 2015 11:13

    Content type: Research

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  12. Cav3.2 channels facilitate nociceptive transmission and are upregulated in DRG neurons in response to nerve injury or peripheral inflammation. We reported that this enhancement of Cav3.2 currents in afferent n...

    Authors: Vinicius M Gadotti, Agustin Garcia Caballero, N Daniel Berger, Clare M Gladding, Lina Chen, Tom A Pfeifer and Gerald W Zamponi

    Citation: Molecular Pain 2015 11:12

    Content type: Research

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  13. Leukotriene B4 (LTB4) is a potent lipid mediator of inflammation, and its biological effects are mediated primarily through the high affinity LTB4 receptor BLT1. Although numerous studies have reported that LTB4-...

    Authors: Miho Asahara, Nobuko Ito, Takehiko Yokomizo, Motonao Nakamura, Takao Shimizu and Yoshitsugu Yamada

    Citation: Molecular Pain 2015 11:11

    Content type: Research

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  14. Paclitaxel, a powerful anti-neoplastic drug, often causes pathological pain, which significantly reduces the quality of life in patients. Paclitaxel-induced pain includes pain that occurs immediately after pac...

    Authors: Xisheng Yan, Dylan W Maixner, Ruchi Yadav, Mei Gao, Pei Li, Michael G Bartlett and Han-Rong Weng

    Citation: Molecular Pain 2015 11:10

    Content type: Research

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  15. Central pain syndrome is characterized by a combination of abnormal pain sensations, and pain medications often provide little or no relief. Accumulating animal and clinical studies have shown that impairments...

    Authors: Hsiang-Chin Lu, Wei-Jen Chang, Yung-Hui Kuan, Andrew Chih-Wei Huang and Bai Chuang Shyu

    Citation: Molecular Pain 2015 11:9

    Content type: Research

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  16. Artemin, a member of the glial cell line-derived neurotrophic factor family, is known to have a variety of neuronal functions, and has been the subject of attention because it has interesting effects, includin...

    Authors: Yasuko Ikeda-Miyagawa, Kimiko Kobayashi, Hiroki Yamanaka, Masamichi Okubo, Shenglan Wang, Yi Dai, Hideshi Yagi, Munetaka Hirose and Koichi Noguchi

    Citation: Molecular Pain 2015 11:8

    Content type: Research

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  17. It has been demonstrated that administration of T-type calcium channel (TCC) inhibitors could relieve the neuropathic pain by intraperitoneally or intrathecally. TCCs are not only expressed in dorsal root gang...

    Authors: Feng-Yan Shen, Zhi-Yu Chen, Wei Zhong, Li-Qing Ma, Chong Chen, Zhou-Jing Yang, Wei-Lin Xie and Ying-Wei Wang

    Citation: Molecular Pain 2015 11:7

    Content type: Research

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  18. The G-protein-coupled receptor 40 (GPR40) is suggested to function as a transmembrane receptor for medium- to long-chain free fatty acids and is implicated to play a role in free fatty acids-mediated enhanceme...

    Authors: Prasanna Karki, Takashi Kurihara, Tomoya Nakamachi, Jun Watanabe, Toshihide Asada, Tatsuki Oyoshi, Seiji Shioda, Megumu Yoshimura, Kazunori Arita and Atsuro Miyata

    Citation: Molecular Pain 2015 11:6

    Content type: Research

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  19. Cell-based therapy may hold promise for treatment of chronic pain. Mesenchymal stem cells (MSCs) are readily available and robust, and their secretion of therapeutic peptides can be enhanced by genetically eng...

    Authors: Hongwei Yu, Gregory Fischer, Allison D Ebert, Hsiang-En Wu, Xiaowen Bai and Quinn H Hogan

    Citation: Molecular Pain 2015 11:5

    Content type: Research

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  20. In anesthetized rats and conscious humans, a gentle touch using a soft disc covered with microcones (with a texture similar to that of a finger), but not with a flat disc, inhibits nociceptive somatocardiac re...

    Authors: Nobuhiro Watanabe, Mathieu Piché and Harumi Hotta

    Citation: Molecular Pain 2015 11:4

    Content type: Research

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  21. Autophagy is a homeostatic degradative process essential for basal turnover of long-lived proteins and organelles as well as for removal of dysfunctional cellular components. Dysregulation of the autophagic ma...

    Authors: Laura Berliocchi, Maria Maiarù, Giuseppe Pasquale Varano, Rossella Russo, Maria Tiziana Corasaniti, Giacinto Bagetta and Cristina Tassorelli

    Citation: Molecular Pain 2015 11:3

    Content type: Research

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  22. The treatment of spinal cord injury (SCI)-induced neuropathic pain presents a challenging healthcare problem. The lack of available robust pharmacological treatments underscores the need for novel therapeutic ...

    Authors: Farinaz Nasirinezhad, Shyam Gajavelli, Blake Priddy, Stanislava Jergova, James Zadina and Jacqueline Sagen

    Citation: Molecular Pain 2015 11:2

    Content type: Research

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  23. Itch-producing compounds stimulate receptors expressed on small diameter fibers that innervate the skin. Many of the currently known pruritogen receptors are Gq Protein-Coupled Receptors (GqPCR), which activate P...

    Authors: Manouela V Valtcheva, Steve Davidson, Chengshui Zhao, Michael Leitges and Robert W Gereau IV

    Citation: Molecular Pain 2015 11:1

    Content type: Research

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  24. Leaders in the fields of Temporomandibular Disorders (TMD) and its accompanying overlapping pain conditions presented their latest findings at the Seventh Scientific Meeting of The TMJ Association, September 7...

    Authors: Diane H Munzenmaier, Joan Wilentz and Allen W Cowley Jr

    Citation: Molecular Pain 2014 10:72

    Content type: Meeting report

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  25. Authors: Roy C Levitt, Gerald Z Zhuang, Benjamin Keeler, Jeff Grant, Laura Bianchi, Eugene S Fu, Yan Ping Zhang, Diana M Erasso, Jian Guo Cui, Tim Wiltshire, Qiongzhen Li, Shuanglin Hao, Konstantinos D Sarantopoulos, Keith Candiotti, Shad B Smith, William Maixner…

    Citation: Molecular Pain 2014 10(Suppl 1):O7

    Content type: Oral presentation

    Published on:

    This article is part of a Supplement: Volume 10 Supplement 1